General Objective: Develop a multicomponent nanostructure for the intracellular delivery of anti-miR-33 in a cellular model of foam cells (macrophages): an experimental perspective of nanomedicine in atherosclerosis.
Specific objectives:
- Determine the best in silico nanostructure candidates using computational chemistry tools.
- Synthesize multicomponent nanostructures for intracellular delivery of anti-miR-33.
- Characterize multicomponent nanostructures using metrology techniques.
- Establish the in vitro model of oxLDL-induced macrophage-derived foam cells.
- To evaluate the functionality of the nanostructures for the intracellular delivery of anti-miR-33 in the in vitro foam cell model.
Participating Institutions:
ESPE, USFQ, UTPL, CLY DENT SA
Participants:
Project Director Rodrigo Marcelo Grijalva Silva
- Miguel Angel Mendez Silva
- Omar Germán Malagón Avilés
- Yolanda Del Rocío Angulo Paredes
- Lourdes Magdalena Orejuela Escobar
- Andrea Carolina Landázuri Flores
- Andrea Cristina Montero Oleas
- Gianluca Gilardoni
- Second Vladimir Morocho Zaragocin
- Daniel Gregorio Aguilera Pesantes
- Doménica Alejandra Vargas Arias
- Jessica Tatiana Lara Palacios
- Arleth Estefania Gualle Brito
- Sandra Stefany Espinosa Tapia
Awarded budget: $30788,27
Project status: In process
