General Objective: Develop a platform based on GQDs for the efficient transport of genes and drugs applied in in vitro models of tumors with the highest incidence in Ecuador.
Specific objectives:
- Synthesize and characterize GQDs starting from graphite.
- Model the interaction between GQDs with both DNA bases and a drug of interest using ab-initio methods.
- To evaluate the binding of genes and the drug of interest used in antitumor treatments with GQDs.
- To evaluate in vitro the antitumor activity of GQD complexes with both the genes and the drug of interest in human tumor lines.
- To evaluate in vitro the cytotoxicity of GQD complexes with both the genes and the drug of interest in reference non-tumor cell lines.
Participating Institutions:
UTE, EPN, UTA.
Participants:
Project Director Rebeca Eugenia González Pastor
- Henrry Marcelo Osorio Calvopiña
- Richard Augusto Rivera Escobar
- Cristina Jeanneth Rodríguez Polit
Awarded budget: $38500,00
Project Status: Completed
