General Objective: To evaluate the use of mitochondria transplantation to improve tissue regeneration of a cutaneous surgical wound in preclinical trials.
Specific objectives
- Generation and optimization of the mouse surgical incision model based on monitoring of regeneration dynamics (histological analysis and expression of Epidermal Growth Factor EGF, Hepatocyte growth Factor HGF, Basic Fibroblast Growth Factor bFGF genes), expression panel of genes related to the dynamics of inflammation such as TNF-α, IL-12, IL-6, IL-10, TGF-β and IL-1β) analysis of the presence and types of bacteria (classification of pathogenic bacteria).
- Determination and evaluation of the concentration of mitochondria with better results in the regeneration of the surgical wound in mice. regeneration dynamics (histological analysis and expression of Epidermal Growth Factor EGF, Hepatocyte growth Factor HGF, Basic Fibroblast Growth Factor bFGF genes), expression panel of genes related to inflammation dynamics such as TNF-α, IL-12, IL- 6, IL-10, TGF-β and IL-1β) analysis of the presence and types of bacteria (classification of pathogenic bacteria).
- To test the use of mitochondria in comparison with other cellular and pharmacological therapies used in the market. regeneration dynamics (histological analysis and expression of Epidermal Growth Factor EGF, Hepatocyte growth Factor HGF, Basic Fibroblast Growth Factor bFGF genes), expression panel of genes related to inflammation dynamics such as TNF-α, IL-12, IL- 6, IL-10, TGF-β and IL-1β) analysis of the presence and types of bacteria (classification of pathogenic bacteria).
Participating Institutions:
USFQ, UPS, UTN, BIOCELLS.
Participants:
Director of the MD project. Francisco Cabrera, Ph.D.
- Francisco Cabrera
- Ramiro Diaz
- Fernando Torres
- Fabian Narvaez
- Christian Larenas
- Peter Beard
- Tania Sulca
- gabriel lopez
Awarded budget: $63072
Project status: Signing of agreements.
