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Santiago Ruilova

"In Silico" Discovery of New Tyrosinase Enzyme Inhibiting Depigmenting Agents with Therapeutic and Industrial Applications

Executive Summary: Melanogenesis disorders, hyper-pigmentation, age spots, as well as some forms of skin cancer are associated with the overproduction of melanin in the basal layers of the skin. The production of melanin is catalyzed in the first steps of the biochemical pathway by the enzyme tyrosinase (EC.1.14.18.1), […]

Discovery “in silico” of New Depigmenting Agents Inhibitors of the Tyrosinase Enzyme with Therapeutic and Industrial Applications Read More »

Spatial Representation of the climatic teleconnections in the precipitation of Ecuador

Executive Summary: Climate teleconnections show remote, large-scale relationships between distant points on Earth. They are known to produce anomalies and variability in the precipitation of a region. Their study is related to the ability to anticipate flood and drought events, which have impacts on agricultural activities and risk management.

Spatial Representation of the climatic teleconnections in the precipitation of Ecuador Read More »

Automatic processing techniques applied to the analysis and prediction of drug use

Executive Summary: Background and justification. The consumption of alcohol and other drugs continues to constitute one of the main public health problems due to its consequences for the consumer and their environment, including health problems, domestic violence and loss of productivity in Ecuador. However, prevention programs and/or public action policies

Automatic processing techniques applied to the analysis and prediction of drug use Read More »

Determine the amount of greenhouse gas emissions in cocoa production in the Vinces community, in order to reduce the associated environmental impact.

Year 2020 IES USFQ Republican Cocoa Organization Amount Awarded $10,000.00 Problem: Determine the amount of greenhouse gas emissions in cocoa production in the community of Vinces, in order to reduce the associated environmental impact. Solution Application of methodologies that allow measuring, documenting and making transparent the actions of

Determine the amount of greenhouse gas emissions, in the production of cocoa in the community of Vinces, in order to reduce the associated environmental impact Read More »

Mechanical Spectroscopy: Transport and interaction radiation matter

Executive Summary: The discovery of carbon nanotubes, graphene and other allotropes of carbon have given rise to a new era of condensed matter physics of real life low dimensional systems that were once thought to be only in the imagination. Many old theoretical treatments and ideas on these exotic materials have come to life in experiments[1-5]

Mechanical Spectroscopy: Transport and interaction radiation matter Read More »

Assessment of biological interactions and Ecosystem Services of insectivorous bats through optical and acoustic technologies

Executive Summary: The conservation of Ecuador's biological diversity is fundamental for national sustainable development but can only be guaranteed to the extent that the breadth and multiplicity of interrelationships between species and the environment are known, as well as the impact that human activities cause to the environment and habitats. He

Assessment of biological interactions and Ecosystem Services of insectivorous bats through optical and acoustic technologies Read More »

Evaluation of the effects of socioeconomic activities in the change of land use and climate change in the threats to floods and droughts in the Tomebamba river basin

Executive Summary: The determining factors of global changes are: the decline of biodiversity, changes in atmospheric composition, changes in land cover and changes in climate. Of these factors, the last two are the most important in Andean basins, since they can trigger hydroclimatic extremes and cause

Evaluation of the effects of socioeconomic activities on land use change and climate change on threats to floods and droughts in the Tomebamba river basin Read More »

Development of an early warning prototype using EWBS and interactive content on Digital TV to minimize the risk of affectation to the population in case of natural phenomena

Executive Summary: The Spatial Data Infrastructure of the University of Cuenca is a project that has been maturing since 2008 and that has allowed many other functionalities to be explored around it. Thus, as a result of several investigations, they have achieved products such as the IDE Red CEDIA , the GT-IDE, LaVCiTE, OntoRisk, among others, where the

Development of an early warning prototype using EWBS and interactive content on Digital TV to minimize the risk of affectation to the population in case of natural phenomena Read More »

Engineering of Saccharomyces boulardii for the production of butyrate and evaluation of its in vitro effect on the structure and function of the intestinal epithelium and macrophages

Executive Summary: Chronic non-communicable diseases (NCDs) are a global public health problem. NCDs, including obesity, hypertension, metabolic syndrome, cancer, share characteristics in relation to changes in the intestinal microbiota associated with an increase in the permeability of the intestinal epithelium. Within this context, short chain fatty acids (SCFAs)

Engineering of Saccharomyces boulardii for the production of butyrate and evaluation of its in vitro effect on the structure and function of the intestinal epithelium and macrophages Read More »

Mechanical, mineralogical and computational characterization of Ecuadorian soil: a first nationwide database

Executive Summary: Long-term goal In the long term, it is planned to have: (1) A consolidated research group in modeling and simulation, (2) Supported by high-performance computing tools, (3) that serve as a basis to generate educational processes and dissemination of knowledge in the line of granular micro-mechanics with a view to generating capacity

Mechanical, mineralogical and computational characterization of Ecuadorian soil: a first nationwide database Read More »