General Objective: Establish the relationship between the structure of a series of synthetic chalcones and their biological activities through QSAR strategies, considering criteria of substituent effects, electronic density, atomic charge and Bader analysis.
Specific objectives:
- To determine the biological activity of a series of synthetic chalcones in "in vitro" tests that will include antioxidant and inhibitory activity of the glucoside enzyme involved in the development of metabolic diseases.
- Establish the structure-activity relationships of the series of compounds under study applying QSAR methodologies.
- Validate the model obtained and indicate candidate structures for drug development.
- Strengthen the expertise and participation of RedFármacos researchers through real meetings and disseminate the results through an international scientific publication in a peer-reviewed and indexed high-impact journal.
Participating Institutions:
USFQ, UCUECA, UTPL.
Participants:
- Cesar Zambrano
- Maria Elena Cazar Ramirez
- Silvia Gonzalez Perez
- Luis Rincon
- Ximena Veronica Jaramillo Fierro
- Victor Postligua
- Valeria Alexandra Puga C
- Maritza Raphaela Ochoa Castro
- Wilson Giovanni Larriva
Awarded budget: $40000
Project status: Finished
