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Seroprevalence of IgG and IgA antibodies to SARS-CoV-2 in a population over 18 years of age, with moderate risk of exposure and associated factors, in two Andean cities of Ecuador, during the year 2022. Longitudinal study

General Objective: Estimate the seroprevalence rate of IgG and IgA anti SARS-CoV-2 antibodies over the course of 9 months of observation in people over 18 years of age, with moderate risk of exposure and associated factors, in two Andean cities of Ecuador, during the year 2022.

Specific objectives

  • Estimate the cumulative incidence rate of seropositivity at 3, 6 and 9 months of observation in the entire study group and by sex, age, city and post-vaccination against COVID-19 during the year 2022.
  • Estimate the median life expectancy of global seropositivity (IgG anti-SARS-CoV-2) adjusted by sex, age, city and post-vaccination against COVID-19 during the year 2022.
  • To estimate the mucosal immune response rate by measuring IgA anti-SARS-CoV-2 in saliva, at 3, 6, and 9 months and post-vaccination against COVID-19.
  • Estimate the susceptible fraction (anti-COVID-19 IgG – negative antibody) of the study population after 9 months of follow-up during the year 2022, considering the post-vaccination time against COVID-19.
  • Determine the risk factors for exposure to SARS-CoV-2 in the study group during the year 2022, according to the indicators of the World Health Organization, WHO-ISARIC data collection form.

Participating Institutions:

UIE, ESPE, UTA.

Participants:

Director of the project Natalia Cristina Romero Sandoval.

  • Ana Patricia Jimenez Arias
  • Ricardo Javier Recalde Navarrete
  • Jose Eduardo Leon Rojas

Awarded budget: $28231,73

Project status: In progress.