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Transcriptomics and proteomics applied to the discovery of skin peptides from the frog Agalychnis spurrelli with anticancer and anti-Trypanosoma cruzi activity

General Objective: Implement transcriptomic analysis as a tool to accelerate the discovery of anticancer and anti-T peptides. cruzi.

Specific objectives:

  • Standardize transcriptomic analysis of A. spurrelli skin using Illumina and Nanopore sequencing.
  • Characterize the primary sequence of A. spurrelli skin peptides by cloning, transcriptomics and proteomics.
  • Determine the activity against cancer cells and T. cruzi of two synthetic peptides from A. spurrel

Participating Institutions:

IKIAM, PUCE, UPS.

Participants:

Project Director Carolina Del Carmen Proaño Bolaños

  • Giovanna Cristina Moran Marcillo
  • Walter Armando Quilumbaquin Alba
  • Jessica Jacqueline Verdesoto Prado
  • Miryan Rosita Rivera Íñiguez
  • Jaime Alfredo Costales Cordero
  • Mateo Alejandro Salazar Salazar
  • Ana Cristina Cevallos Bonifaz
  • Andrea Denisse Benitez Quintana
  • Marco Vinicio Ibarra Martinez
  • Ailín Amira Blasco Zúñiga

Awarded budget: $50000,00

Project status: In process