General Objective: To evaluate the antiparasitic activity of at least 5 peptides from the cruzioseptin, dermaseptin and pictuseptin families derived from the skin of Ecuadorian amphibians against Plasmodium, Trypanosoma and Leishmania, the causative agents of malaria, Chagas disease and leishmaniasis respectively.
Specific objectives
- Synthesize and purify at least 5 peptides from the cruzioseptin, dermaseptin and pictuseptin families derived from the skin of Ecuadorian amphibians.
- Determine the cytotoxicity of at least 5 synthetic peptides.
- Determine the activity against Plasmodium falciparum of at least 5 synthetic peptides.
- Determine the activity against Trypanosoma cruzi of at least 5 synthetic peptides.
- Determine the activity against Leishmania mexicana of at least 5 synthetic peptides.
- Explore the mechanism of action of peptides using bioinformatics tools
Participating Institutions:
PUCE, USFQ, IKIAM.
Participants:
Director of the project Miryan Rosita Rivera Íñiguez.
- Miryan Rosita Rivera Íñiguez
- Jaime Alfredo Costales Cordero
- Fabian Ernesto Saenz Calderon
- Lorena Maribel Meneses Olmedo
- Ailin Amira Blasco Zúñiga
- Mateo Alejandro Salazar Salazar
- Sonia Elizabeth Zapata Mena
- Franklin Andre Espinosa Mendez
- Carolina del Carmen Proaño Bolanos
- Giovanna Cristina Moran Marcillo
- Nina Quilla Espinosa de los Monteros Silva
Awarded budget: $405500
Project status: Signing of agreements.
